HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders
نویسندگان
چکیده
منابع مشابه
EBV-positive diffuse large B-cell lymphoma of the elderly.
Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly, initially described in 2003, is a provisional entity in the 2008 World Health Organization classification system and is defined as an EBV-positive monoclonal large B-cell proliferation that occurs in patients >50 years of age and in whom there is no known immunodeficiency or history of lymphoma. These tumors...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Age-related Epstein-Barr virus (EBV)–associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients
1Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya; 2Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto; 3Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya; 4Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya; 5Department of Pathology, Saitama Medical Center, Saitama Medical Sch...
متن کاملAge-related Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients.
Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder (aEBVLPD) is a disease group characterized by EBV-associated large B-cell lymphoma in elderly without predisposing immunodeficiency. In nearly one- third of cases, aEBVLPD occurs as a polymorphous subtype with reactive cell-rich components, bearing a morphologic similarity to classic Hodgkin lymphoma (cHL). The aim of...
متن کاملEBV in Hodgkin Lymphoma
Up to 40% of Hodgkin lymphoma (HL) cases are associated with the Epstein-Barr virus (EBV). Clonal viral genomes can be found in the HL tumor cells, the Hodgkin Reed-Sternberg cells (HRS). The latent infection results in expression of the viral oncogenes LMP1 and LMP2A which contribute to generate the particular phenotype of the HRS cells. EBV does not only undergo epigenetic changes of its geno...
متن کاملTarget cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma.
BACKGROUND Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) encompasses a histologically broad range of lesions, arising from the expanded pool of EBV-infected B cells in the immunocompromised host. Identification of the precise cellular origin of these tumours could clarify their pathogenesis. METHODS Of 13 cases of EBV-positive cases of PTLD characteris...
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ژورنال
عنوان ژورنال: International Journal of Hematology
سال: 2020
ISSN: 0925-5710,1865-3774
DOI: 10.1007/s12185-020-02897-8